Modification of postsynaptic structure

Across TCGA cell cohorts, RNA activity of the Modification of postsynaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGKE, MAN2C1, and FAM13B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DGKE grouped by Modification of postsynaptic structure-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DGKE →	-1.936	-1.730	.002	<.001	3	4
BLOOD_Lymphoma	MAN2C1 →	-1.682	-1.781	<.001	.005	3	3
LARGE_INTESTINE	FAM13B →	-0.789	-1.114	<.001	<.001	3	3
LUNG_SCLC	CRNKL1 →	-0.905	-1.583	.001	<.001	3	3
LUNG_SCLC	SERINC1 →	-0.950	-1.413	.001	.003	3	3
LUNG_SCLC	DIAPH2 →	+1.979	+1.390	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DGKE by Modification of postsynaptic structure activity — SOFT_TISSUE

Explore this box plot interactively →