Modification of postsynaptic structure

Across TCGA cell cohorts, RNA activity of the Modification of postsynaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTF2, EHD1, and SPATA20, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of postsynaptic structure activity versus RTF2 in OESOPHAGUS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RTF2 →	+0.586	+0.250	.008	.005	3	6
BONE	EHD1 →	+1.227	+0.322	.006	.006	3	5
BLOOD_Leukemia	SPATA20 →	+1.312	+0.196	.003	<.001	3	5
BLOOD_Leukemia	ARPC2 →	+0.772	+0.171	.002	.005	3	5
BLOOD_Leukemia	AHRR →	+1.889	+0.191	<.001	<.001	3	4
LARGE_INTESTINE	PYGM →	-0.210	-0.198	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099010 vs RTF2 — OESOPHAGUS

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