Vesicle-mediated transport in synapse

Across TCGA patient cohorts, RNA activity of the Vesicle-mediated transport in synapse pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUNDC2P4, SLC10A3, and ANGPTL6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport in synapse activity versus FUNDC2P4 in OV (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FUNDC2P4 →	-0.201	-0.133	.004	<.001	3	2
COAD	SLC10A3 →	+0.403	+0.124	<.001	.001	3	1
COAD	ANGPTL6 →	+0.221	+0.138	<.001	.006	3	1
COAD	RADX →	+0.571	+0.150	.003	<.001	3	1
COAD	VMA21 →	+0.366	+0.159	.004	.006	3	1
COAD	ZDHHC19 →	+0.167	+0.154	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099003 vs FUNDC2P4 — OV

Explore this scatter interactively →