Vesicle-mediated transport in synapse

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated transport in synapse pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC36A1, CDC16, and NBR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC36A1 grouped by Vesicle-mediated transport in synapse-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC36A1 →	-0.953	-0.230	<.001	<.001	3	4
BLOOD_Myeloma	CDC16 →	-0.911	-0.193	.001	.001	3	4
BLOOD_Leukemia	NBR1 →	-0.780	-0.149	.008	.009	3	4
URINARY_TRACT	GSK3A →	-0.585	-0.335	.004	.009	3	4
STOMACH	DNM1 →	-3.375	-0.319	<.001	.001	3	4
STOMACH	KLHDC8B →	-2.285	-0.266	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC36A1 by Vesicle-mediated transport in synapse activity — OESOPHAGUS

Explore this box plot interactively →