Dendritic transport of ribonucleoprotein complex

pathway activity — cross-omics
GO:0098961Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Dendritic transport of ribonucleoprotein complex pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLK, PURA, and RAD50, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UVMPOLK →+1.075+0.053<.001<.001334
KIRPPURA →+1.139+0.079<.001<.001334
UVMRAD50 →+1.108+0.054<.001<.001333
THYMMATR3 →+0.867+0.051<.001<.001333
UVMDMXL1 →+1.393+0.056<.001<.001333
UVMSCAMP1 →+1.084+0.052<.001<.001333
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration