Receptor diffusion trapping

Across TCGA patient cohorts, RNA activity of the Receptor diffusion trapping pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL1RAP, TANC2, and CD38, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor diffusion trapping activity versus IL1RAP in GBM (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL1RAP →	+0.582	+0.097	.002	.002	3	6
PDAC	TANC2 →	+0.275	+0.063	.001	<.001	3	4
BRCA	CD38 →	-0.702	-0.045	<.001	.002	2	5
PDAC	CTSS →	-0.428	-0.070	<.001	<.001	3	4
LSCC	IL16_S922 →	-0.498	-0.080	<.001	<.001	3	4
BRCA	MZB1 →	-1.073	-0.079	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098953 vs IL1RAP — GBM

Explore this scatter interactively →