Receptor diffusion trapping

Across TCGA cell cohorts, RNA activity of the Receptor diffusion trapping pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, RAB4A, and RHBDD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC2 grouped by Receptor diffusion trapping-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RAC2 →	+2.050	+0.804	.003	.007	3	4
OVARY	RAB4A →	-0.840	-1.178	.002	.004	3	4
SKIN	RHBDD3 →	-0.740	-1.449	.004	<.001	3	4
SKIN	FAM229B →	-1.174	-1.502	.003	<.001	3	4
OVARY	SRPX2 →	+2.260	+1.326	<.001	<.001	3	3
OVARY	NID1 →	+2.710	+1.192	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC2 by Receptor diffusion trapping activity — OVARY

Explore this box plot interactively →