Receptor diffusion trapping

Across TCGA cell cohorts, RNA activity of the Receptor diffusion trapping pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSX6P, EEA1, and DDX27, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSX6P grouped by Receptor diffusion trapping-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SSX6P →	+0.173	+1.213	.006	.002	2	6
LARGE_INTESTINE	EEA1 →	-0.188	-1.290	.002	.004	3	4
LARGE_INTESTINE	DDX27 →	-0.485	-1.358	.002	<.001	3	4
BREAST	RP1 →	-0.161	-1.181	.003	<.001	3	4
BLOOD_Lymphoma	PSMA7 →	-0.800	-2.401	.006	.005	2	5
BLOOD_Lymphoma	FGL1 →	-0.320	-2.241	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSX6P by Receptor diffusion trapping activity — BLOOD_Leukemia

Explore this box plot interactively →