Dendritic transport

Across TCGA patient cohorts, RNA activity of the Dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB4, GCOM1, and SGMS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic transport activity versus KCNMB4 in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KCNMB4 →	+1.134	+0.135	<.001	<.001	3	4
GBM	GCOM1 →	-0.461	-0.096	.003	.006	3	4
GBM	SGMS2 →	-0.506	-0.083	<.001	.005	3	4
BRCA	LINC02019 →	-0.330	-0.120	.007	.004	3	4
GBM	ZKSCAN7-AS1 →	+0.461	+0.112	.007	.005	3	4
LSCC	OFD1P17 →	+0.443	+0.131	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098935 vs KCNMB4 — GBM

Explore this scatter interactively →