Dendritic transport

Across TCGA cell cohorts, RNA activity of the Dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF585B, ARFGEF3, and THEM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF585B grouped by Dendritic transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF585B →	+0.823	+0.129	.006	.001	3	5
UPPER_AERODIGESTIVE_TRACT	ARFGEF3 →	+1.208	+0.195	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	THEM6 →	+1.204	+0.202	.006	<.001	3	3
CNS	SLC22A23 →	-1.013	-0.358	.001	.007	3	3
BLOOD_Lymphoma	SNX16 →	+1.098	+0.294	.005	.007	3	3
OESOPHAGUS	SLC20A2 →	+1.022	+0.159	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF585B by Dendritic transport activity — BREAST

Explore this box plot interactively →