Axonal transport

Across TCGA patient cohorts, RNA activity of the Axonal transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1965, VPS13C_S737, and UCHL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal transport activity versus MAP1B_S1965 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1965 →	+0.973	+0.032	<.001	<.001	3	6
LSCC	VPS13C_S737 →	-0.433	-0.033	<.001	<.001	3	6
LSCC	UCHL1 →	+1.138	+0.042	<.001	<.001	3	5
HNSC	TNKS1BP1_S601 →	-0.403	-0.040	.001	.007	3	5
LSCC	MAP2_S833 →	+0.920	+0.028	<.001	<.001	3	5
COAD	ZZEF1 →	-0.212	-0.020	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098930 vs MAP1B_S1965 — LSCC

Explore this scatter interactively →