Axonal transport

Across TCGA patient cohorts, RNA activity of the Axonal transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, RECK, and PPFIA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal transport activity versus MAP1A in LSCC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1A →	+0.903	+0.477	<.001	<.001	3	4
LSCC	RECK →	+0.465	+0.625	.003	.001	3	4
LSCC	PPFIA2 →	+0.320	+0.417	.001	.007	3	4
LSCC	TRPC1 →	+0.578	+0.414	.002	.003	3	4
LSCC	PNMA8B →	+0.308	+0.394	<.001	<.001	3	4
LSCC	ISLR2 →	+0.261	+0.386	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098930 vs MAP1A — LSCC

Explore this scatter interactively →