Axonal transport

Across TCGA cell cohorts, RNA activity of the Axonal transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTP25, GIGYF2, and RIN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UTP25 grouped by Axonal transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UTP25 →	+0.540	+0.227	.002	.004	2	5
BONE	GIGYF2 →	+0.453	+0.315	.009	.005	3	4
OESOPHAGUS	RIN2 →	+1.252	+0.174	.005	.003	3	4
BLOOD_Leukemia	NUP133 →	+0.559	+0.921	.008	.008	3	3
SOFT_TISSUE	PRRG1 →	+1.548	+0.193	<.001	.001	3	3
SOFT_TISSUE	FHL3 →	+0.933	+0.186	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UTP25 by Axonal transport activity — STOMACH

Explore this box plot interactively →