Axonal transport

Across TCGA cell cohorts, RNA activity of the Axonal transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, LGALS1, and MRPS31, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal transport activity versus TGFBI in KIDNEY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TGFBI →	+1.945	+0.380	.003	.005	3	5
LUNG_NSCLC_LUAD	LGALS1 →	+1.658	+0.170	.005	.002	2	6
LUNG_NSCLC_LUAD	MRPS31 →	-0.406	-0.162	.008	<.001	3	5
OVARY	HSPB1 →	+2.107	+0.184	<.001	.004	3	5
BLOOD_Leukemia	ECM1 →	+1.746	+0.641	.001	.003	3	5
LIVER	PCM1 →	-1.803	-0.348	.006	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098930 vs TGFBI — KIDNEY

Explore this scatter interactively →