Vesicle-mediated transport between endosomal compartments

Across TCGA patient cohorts, RNA activity of the Vesicle-mediated transport between endosomal compartments pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, PRKG1, and RPL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport between endosomal compartments activity versus TNS2 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2 →	+0.274	+0.030	<.001	<.001	3	8
BRCA	PRKG1 →	+0.671	+0.047	<.001	<.001	3	8
BRCA	RPL5 →	-0.182	-0.038	<.001	<.001	3	7
LSCC	RPS19 →	-0.174	-0.054	<.001	<.001	3	7
CCRCC	SEPTIN4 →	+0.481	+0.039	.001	<.001	3	7
OV	LZTS1_S233 →	+1.303	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098927 vs TNS2 — BRCA

Explore this scatter interactively →