Vesicle-mediated transport between endosomal compartments

Across TCGA patient cohorts, RNA activity of the Vesicle-mediated transport between endosomal compartments pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, COPZ2, and SRPX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport between endosomal compartments activity versus ACTA2 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTA2 →	+1.136	+0.117	.001	.002	3	9
OV	COPZ2 →	+1.357	+0.303	.001	<.001	3	9
UCEC	SRPX →	+1.096	+0.165	<.001	<.001	3	8
COAD	AEBP1 →	+1.233	+0.431	.001	.003	3	8
LSCC	SPARC →	+1.044	+0.208	<.001	<.001	3	8
PDAC	SGIP1 →	+0.765	+0.279	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098927 vs ACTA2 — UCEC

Explore this scatter interactively →