Postsynaptic signal transduction

Across TCGA patient cohorts, RNA activity of the Postsynaptic signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, MIR223HG, and SAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic signal transduction activity versus THEMIS2 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THEMIS2 →	+0.941	+0.148	<.001	<.001	3	6
HNSC	MIR223HG →	+1.057	+0.160	<.001	<.001	3	6
HNSC	SAT1 →	+0.694	+0.096	<.001	<.001	3	5
HNSC	CPA3 →	+1.561	+0.136	<.001	.001	3	5
HNSC	FPR1 →	+1.130	+0.123	<.001	<.001	3	5
BRCA	GPR171 →	+0.829	+0.169	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098926 vs THEMIS2 — HNSC

Explore this scatter interactively →