Postsynaptic signal transduction

Across TCGA cell cohorts, RNA activity of the Postsynaptic signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME1, SNAPC5, and TRAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic signal transduction activity versus NME1 in BREAST (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NME1 →	-1.458	-1.096	.001	<.001	3	6
SKIN	SNAPC5 →	-0.733	-0.914	.002	.008	3	5
LUNG_NSCLC_LUAD	TRAP1 →	-0.747	-0.729	.001	.002	3	5
BLOOD_Myeloma	KDM2A →	+0.748	+1.146	.009	<.001	3	4
SOFT_TISSUE	TBC1D22B →	+0.653	+1.376	.002	<.001	2	5
BLOOD_Leukemia	EHD2 →	+2.616	+0.677	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098926 vs NME1 — BREAST

Explore this scatter interactively →