Retrograde trans-synaptic signaling by lipid

Across TCGA patient cohorts, RNA activity of the Retrograde trans-synaptic signaling by lipid pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT2, ITGA5, and ANTXR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde trans-synaptic signaling by lipid activity versus STAT2 in OV (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STAT2 →	-0.321	-0.056	.001	.002	3	5
COAD	ITGA5 →	-0.435	-0.056	.004	<.001	3	5
OV	ANTXR2 →	-0.425	-0.047	.002	.008	3	5
GBM	PLCB1 →	+0.765	+0.110	<.001	<.001	3	5
CCRCC	FABP5 →	+0.645	+0.068	<.001	<.001	2	6
COAD	APOO →	+0.286	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098920 vs STAT2 — OV

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