Retrograde trans-synaptic signaling by lipid

Across TCGA patient cohorts, RNA activity of the Retrograde trans-synaptic signaling by lipid pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLIP, SMIM43, and SLCO4C1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde trans-synaptic signaling by lipid activity versus MLIP in BRCA (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MLIP →	+0.168	+0.136	.002	.001	3	4
GBM	SMIM43 →	+0.694	+0.710	<.001	<.001	3	4
CCRCC	SLCO4C1 →	+0.864	+0.805	.002	.002	3	4
CCRCC	AMIGO1 →	+0.955	+0.612	<.001	.004	3	4
BRCA	IGLV3-27 →	+1.233	+0.132	.005	<.001	3	3
BRCA	IGKV1-5 →	+2.214	+0.164	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098920 vs MLIP — BRCA

Explore this scatter interactively →