Retrograde trans-synaptic signaling

Across TCGA patient cohorts, RNA activity of the Retrograde trans-synaptic signaling pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM2, NEGR1, and KPNA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde trans-synaptic signaling activity versus JAM2 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAM2 →	+0.568	+0.154	.005	.002	3	5
GBM	NEGR1 →	+0.739	+0.768	<.001	<.001	3	5
GBM	KPNA2 →	-0.357	-0.620	.003	<.001	3	5
GBM	HS6ST3 →	+1.015	+0.764	<.001	<.001	3	5
UCEC	MAGOH →	-0.573	-0.177	.005	.002	3	4
UCEC	CGAS →	-0.696	-0.248	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098917 vs JAM2 — UCEC

Explore this scatter interactively →