Retrograde trans-synaptic signaling

Across TCGA patient cohorts, RNA activity of the Retrograde trans-synaptic signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FARP1, CRMP1, and HSPA12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde trans-synaptic signaling activity versus FARP1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FARP1 →	+0.375	+0.560	<.001	<.001	3	6
GBM	CRMP1 →	+0.539	+0.960	<.001	<.001	3	4
GBM	HSPA12A →	+0.777	+0.744	<.001	<.001	3	4
GBM	HYI →	+0.392	+1.032	<.001	<.001	3	4
BRCA	PALB2_S660 →	-0.458	-0.439	<.001	<.001	3	4
GBM	PURA →	+0.375	+0.879	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098917 vs FARP1 — BRCA

Explore this scatter interactively →