Retrograde trans-synaptic signaling

Across TCGA cell cohorts, RNA activity of the Retrograde trans-synaptic signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5, STRBP, and SLC35G1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde trans-synaptic signaling activity versus FABP5 in LUNG_SCLC (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FABP5 →	+5.293	+1.862	<.001	<.001	3	6
SOFT_TISSUE	STRBP →	+2.169	+1.718	<.001	<.001	3	5
PANCREAS	SLC35G1 →	+1.368	+1.527	<.001	<.001	3	5
OVARY	TYMS →	+1.303	+1.269	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	LOXL1 →	-3.280	-0.309	<.001	.001	3	5
LARGE_INTESTINE	LBH →	-2.369	-0.751	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098917 vs FABP5 — LUNG_SCLC

Explore this scatter interactively →