Membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA2D2, SNHG3, and GARS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during ventricular cardiac muscle cell action potential activity versus CACNA2D2 in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CACNA2D2 →	+1.278	+0.543	<.001	.001	3	4
LUAD	SNHG3 →	-0.722	-0.383	<.001	.004	3	3
UCEC	GARS1 →	-0.264	-0.321	.007	.004	3	3
UCEC	NOCT →	-0.600	-0.553	.003	.001	3	3
BRCA	KCNK5 →	-1.071	-0.499	.002	.002	3	3
CCRCC	SRSF5 →	+0.312	+0.326	.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098915 vs CACNA2D2 — BRCA

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