Membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFOD1, NUP93, and RPA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OGFOD1 grouped by Membrane repolarization during ventricular cardiac muscle cell action potential-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OGFOD1 →	+0.805	+1.336	.006	.003	3	6
LIVER	NUP93 →	+0.766	+1.221	.004	.006	3	6
UPPER_AERODIGESTIVE_TRACT	RPA1 →	+0.961	+1.127	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SF3B3 →	+1.016	+1.525	.003	<.001	3	5
OVARY	RIC8B →	+0.921	+1.298	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CHTF8 →	+0.787	+1.127	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OGFOD1 by Membrane repolarization during ventricular cardiac muscle cell action potential activity — OVARY

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