Membrane repolarization during atrial cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during atrial cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNQ1, KCNA5, and BACH2, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during atrial cardiac muscle cell action potential activity versus KCNQ1 in CHOL (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	KCNQ1 →	+1.849	+0.198	<.001	<.001	3	24
PAAD	KCNA5 →	-0.973	-0.105	<.001	<.001	3	17
THYM	BACH2 →	-0.955	-0.111	<.001	<.001	3	17
HNSC	ZEB1 →	-0.883	-0.077	<.001	<.001	3	17
THYM	CAMK4 →	-1.932	-0.097	<.001	<.001	3	17
HNSC	GIMAP4 →	-0.966	-0.074	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098914 vs KCNQ1 — CHOL

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