Membrane repolarization during atrial cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane repolarization during atrial cardiac muscle cell action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR1, BLVRA, and HACD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C5AR1 grouped by Membrane repolarization during atrial cardiac muscle cell action potential-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C5AR1 →	-0.114	-0.265	.001	<.001	3	5
KIDNEY	BLVRA →	+0.325	+0.233	<.001	.002	3	5
BLOOD_Leukemia	HACD3 →	+0.216	+1.456	.001	.003	3	5
BLOOD_Leukemia	SYNCRIP →	+0.256	+1.312	.001	<.001	3	4
STOMACH	PIKFYVE →	+0.231	+1.731	.007	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	DNM1L →	+0.291	+0.230	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C5AR1 by Membrane repolarization during atrial cardiac muscle cell action potential activity — UPPER_AERODIGESTIVE_TRACT

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