Regulation of ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PKP2, DSG2, and JUP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ventricular cardiac muscle cell action potential activity versus PKP2 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PKP2 →	+1.011	+0.065	<.001	.001	3	8
HNSC	DSG2 →	+0.533	+0.067	<.001	<.001	3	7
LSCC	JUP →	+0.520	+0.046	.001	.005	3	7
BRCA	PKP2_S251 →	+1.136	+0.085	<.001	<.001	3	7
GBM	DSG2_S703 →	+1.263	+0.096	<.001	.001	3	6
LSCC	DSG2_T922 →	+0.438	+0.041	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098911 vs PKP2 — LUAD

Explore this scatter interactively →