Regulation of ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, PERP, and PKP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ventricular cardiac muscle cell action potential activity versus DSP in CCRCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DSP →	+1.706	+0.541	<.001	.001	3	8
LSCC	PERP →	+1.404	+0.758	<.001	<.001	3	7
BRCA	PKP2 →	+1.134	+0.656	<.001	<.001	3	7
COAD	FGF7 →	-0.669	-0.271	<.001	<.001	3	6
UCEC	RSPO3 →	-1.198	-0.226	<.001	.001	3	6
COAD	NCF1B →	-0.585	-0.260	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098911 vs DSP — CCRCC

Explore this scatter interactively →