Regulation of ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA1C, PKP2, and DLG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNA1C grouped by Regulation of ventricular cardiac muscle cell action potential-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CACNA1C →	-0.428	-1.594	<.001	<.001	3	8
CNS	PKP2 →	-0.338	-1.046	<.001	.005	3	6
BLOOD_Myeloma	DLG1 →	-0.469	-2.026	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	DSC2 →	-0.198	-1.497	.001	.001	2	7
SOFT_TISSUE	MS4A6A →	-0.166	-0.931	.003	.008	2	6
LIVER	CYB561 →	-0.309	-1.457	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNA1C by Regulation of ventricular cardiac muscle cell action potential activity — OVARY

Explore this box plot interactively →