Regulation of ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BHLHE40, SLC51A, and ZNF883, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BHLHE40 grouped by Regulation of ventricular cardiac muscle cell action potential-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BHLHE40 →	-2.229	-1.103	.009	.004	3	5
SKIN	SLC51A →	-0.600	-1.006	<.001	.004	3	4
OESOPHAGUS	ZNF883 →	-1.349	-1.531	.003	<.001	3	4
STOMACH	TMUB2 →	-0.557	-1.225	.005	.003	3	4
BONE	GPR182 →	+0.180	+1.242	.003	.007	3	4
STOMACH	RPL24 →	+0.562	+1.364	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BHLHE40 by Regulation of ventricular cardiac muscle cell action potential activity — BLOOD_Leukemia

Explore this box plot interactively →