Regulation of ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf116, GALNT3, and TMPRSS4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ventricular cardiac muscle cell action potential activity versus C1orf116 in URINARY_TRACT (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C1orf116 →	+3.675	+0.793	<.001	<.001	3	9
STOMACH	GALNT3 →	+4.439	+0.584	<.001	.001	3	8
OESOPHAGUS	TMPRSS4 →	+2.923	+0.335	<.001	.003	3	8
OVARY	CBLC →	+3.111	+0.488	.001	<.001	3	8
URINARY_TRACT	LAD1 →	+6.002	+0.744	<.001	<.001	3	8
URINARY_TRACT	CDH1 →	+6.772	+0.678	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098911 vs C1orf116 — URINARY_TRACT

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