Regulation of neuronal action potential

Across TCGA patient cohorts, RNA activity of the Regulation of neuronal action potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMR1, SFT2D2, and TMX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuronal action potential activity versus FMR1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FMR1 →	+0.349	+0.113	<.001	<.001	3	7
CCRCC	SFT2D2 →	+0.509	+0.113	.003	.004	3	5
CCRCC	TMX2 →	+0.306	+0.097	.006	.004	3	5
CCRCC	EMC1 →	+0.242	+0.098	.006	.004	3	5
CCRCC	FSCN1_S39 →	-0.711	-0.154	<.001	<.001	3	5
CCRCC	PIGU →	+0.342	+0.106	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098908 vs FMR1 — BRCA

Explore this scatter interactively →