Regulation of neuronal action potential

Across TCGA cell cohorts, RNA activity of the Regulation of neuronal action potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF12, TRAPPC5, and NTN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCF12 grouped by Regulation of neuronal action potential-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TCF12 →	+1.006	+1.335	<.001	<.001	3	5
OESOPHAGUS	TRAPPC5 →	+0.854	+0.853	<.001	<.001	3	4
BONE	NTN4 →	-2.513	-1.603	.006	.002	3	4
LUNG_SCLC	PTRH1 →	+1.305	+1.383	.004	<.001	3	4
BLOOD_Leukemia	MRRF →	+0.406	+0.796	.003	.009	3	4
SOFT_TISSUE	SEPTIN1 →	+0.461	+1.190	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCF12 by Regulation of neuronal action potential activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →