Regulation of membrane repolarization during action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization during action potential pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACNA2D1, SELENOM, and CDC42BPA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during action potential activity versus CACNA2D1 in CCRCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CACNA2D1 →	+0.545	+0.084	<.001	<.001	3	7
OV	SELENOM →	+0.429	+0.054	<.001	.002	3	6
COAD	CDC42BPA →	+0.382	+0.045	<.001	<.001	3	6
COAD	MYO1C →	+0.422	+0.034	<.001	.005	3	6
PDAC	SERPINB7 →	+1.373	+0.062	<.001	.001	3	6
COAD	COL3A1 →	+0.810	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098903 vs CACNA2D1 — CCRCC

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