Regulation of membrane repolarization during action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, MYL9, and CCN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during action potential activity versus CYP1B1 in OV (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP1B1 →	+1.365	+0.577	<.001	<.001	3	9
LSCC	MYL9 →	+1.038	+0.563	<.001	<.001	3	8
OV	CCN4 →	+1.451	+0.647	<.001	<.001	3	8
OV	ACTA2 →	+1.953	+0.680	<.001	<.001	3	8
OV	GLT8D2 →	+1.230	+0.540	<.001	<.001	3	8
OV	CALD1 →	+0.864	+0.574	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098903 vs CYP1B1 — OV

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