Regulation of membrane repolarization during action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1LG2, CAV2, and CAV1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during action potential activity versus PDCD1LG2 in LIVER (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PDCD1LG2 →	+1.564	+0.252	<.001	<.001	3	12
STOMACH	CAV2 →	+3.980	+0.192	<.001	<.001	3	11
STOMACH	CAV1 →	+5.407	+0.212	<.001	<.001	3	11
LIVER	DRAP1 →	+1.333	+0.259	<.001	<.001	3	11
STOMACH	EPB41 →	-1.361	-0.156	.001	.001	3	10
STOMACH	AXL →	+4.430	+0.182	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098903 vs PDCD1LG2 — LIVER

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