Regulation of membrane repolarization during action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane repolarization during action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRCA1, ABHD13, and DUSP23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRCA1 grouped by Regulation of membrane repolarization during action potential-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BRCA1 →	-0.200	-0.251	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ABHD13 →	+0.143	+0.310	.001	<.001	3	3
LARGE_INTESTINE	DUSP23 →	+0.283	+0.275	<.001	.006	3	3
LUNG_SCLC	RHOT2 →	-0.209	-0.271	<.001	.007	3	3
KIDNEY	SLC35F3 →	-0.376	-0.355	.001	.003	3	2
SKIN	TPSD1 →	-0.137	-0.274	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRCA1 by Regulation of membrane repolarization during action potential activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →