Regulation of membrane depolarization during action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIAL4A, MSRA, and THEM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIAL4A grouped by Regulation of membrane depolarization during action potential-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PPIAL4A →	+0.067	+1.749	.001	<.001	3	4
LUNG_NSCLC_LUSC	MSRA →	+1.658	+1.525	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	THEM4 →	+0.842	+1.152	.002	.005	3	3
BLOOD_Lymphoma	HILPDA →	+1.302	+1.492	.001	<.001	2	4
BLOOD_Lymphoma	PLSCR1 →	-4.143	-1.911	.008	<.001	3	3
BLOOD_Myeloma	FTSJ3 →	-0.998	-1.585	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIAL4A by Regulation of membrane depolarization during action potential activity — BLOOD_Lymphoma

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