Regulation of membrane depolarization during action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization during action potential pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK3, RANGRF, and SNRNP27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization during action potential activity versus ANK3 in LARGE_INTESTINE (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANK3 →	+0.776	+0.273	<.001	.001	3	4
BLOOD_Leukemia	RANGRF →	+1.804	+0.524	<.001	<.001	3	3
BLOOD_Lymphoma	SNRNP27 →	-0.489	-0.360	.005	.009	3	3
BLOOD_Lymphoma	CXorf38 →	+1.017	+0.414	.009	<.001	3	3
LARGE_INTESTINE	PPHLN1 →	+0.918	+0.362	<.001	.002	3	3
LARGE_INTESTINE	CHTOP →	+0.711	+0.335	.008	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098902 vs ANK3 — LARGE_INTESTINE

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