Regulation of action potential

Across TCGA patient cohorts, RNA activity of the Regulation of action potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM_S22, CD14, and LIG3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of action potential activity versus VIM_S22 in BRCA (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VIM_S22 →	+0.592	+0.022	.001	.005	3	6
BRCA	CD14 →	+0.431	+0.023	<.001	.004	3	6
GBM	LIG3 →	-0.388	-0.047	<.001	<.001	3	6
CCRCC	SNX7 →	+0.326	+0.027	<.001	.001	3	5
LSCC	PBRM1_S505 →	-0.564	-0.069	.005	.007	3	5
OV	RIPOR1 →	+0.320	+0.030	.004	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098900 vs VIM_S22 — BRCA

Explore this scatter interactively →