Regulation of action potential

Across TCGA cell cohorts, RNA activity of the Regulation of action potential pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA5, CCSAP, and TENM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA5 grouped by Regulation of action potential-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ITGA5 →	-2.142	-1.301	.002	.007	3	5
CNS	CCSAP →	+0.412	+0.666	.007	.007	2	5
LARGE_INTESTINE	TENM3 →	+1.832	+0.623	.001	<.001	3	3
STOMACH	PRELID3A →	+1.277	+0.797	.003	.007	3	3
STOMACH	DUSP18 →	-0.938	-0.865	.001	.006	3	3
STOMACH	TRIP13 →	+1.476	+1.043	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA5 by Regulation of action potential activity — URINARY_TRACT

Explore this box plot interactively →