Regulation of action potential

Across TCGA cell cohorts, RNA activity of the Regulation of action potential pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH3, ACSF2, and TMEM265, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of action potential activity versus CDH3 in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDH3 →	+6.440	+0.422	<.001	.002	3	9
PANCREAS	ACSF2 →	+2.364	+0.462	.003	<.001	3	9
PANCREAS	TMEM265 →	+2.962	+0.492	<.001	<.001	3	8
PANCREAS	MPZL2 →	+3.628	+0.397	.004	.007	2	9
URINARY_TRACT	GPR87 →	+4.122	+0.386	<.001	.006	3	8
BREAST	PLSCR1 →	+1.981	+0.251	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098900 vs CDH3 — URINARY_TRACT

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