"Neurotransmitter receptor transport, endosome to postsynaptic membrane"

Across TCGA patient cohorts, RNA activity of the "Neurotransmitter receptor transport, endosome to postsynaptic membrane" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8orf33, POLR2K, and PCBD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Neurotransmitter receptor transport, endosome to postsynaptic membrane" activity versus C8orf33 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C8orf33 →	+0.714	+0.961	<.001	<.001	3	6
LSCC	POLR2K →	+0.378	+0.688	.008	.009	3	5
UCEC	PCBD1 →	+0.434	+0.667	<.001	<.001	3	5
BRCA	ENY2 →	+0.428	+0.725	.001	.004	3	4
BRCA	MRPL13 →	+0.472	+0.624	.003	.006	3	4
CCRCC	ATP5F1C →	+0.348	+0.851	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098887 vs C8orf33 — BRCA

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