"Neurotransmitter receptor transport, endosome to postsynaptic membrane"

Across TCGA cell cohorts, RNA activity of the "Neurotransmitter receptor transport, endosome to postsynaptic membrane" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIP1, BOP1, and SLC52A2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Neurotransmitter receptor transport, endosome to postsynaptic membrane" activity versus GRIP1 in LIVER (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GRIP1 →	-2.807	-0.231	<.001	.001	3	11
SOFT_TISSUE	BOP1 →	+0.974	+0.174	.001	.003	3	11
BLOOD_Lymphoma	SLC52A2 →	+1.272	+0.138	<.001	<.001	3	10
BLOOD_Myeloma	HGH1 →	+1.138	+0.156	<.001	.006	3	9
BLOOD_Lymphoma	CHRAC1 →	+1.214	+0.165	<.001	<.001	3	9
BLOOD_Lymphoma	PUF60 →	+0.736	+0.128	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098887 vs GRIP1 — LIVER

Explore this scatter interactively →