Synapse pruning

Across TCGA patient cohorts, RNA activity of the Synapse pruning pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QA, TYROBP, and NCF2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse pruning activity versus C1QA in BLCA (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C1QA →	+2.679	+0.103	<.001	<.001	3	32
BLCA	TYROBP →	+2.205	+0.100	<.001	<.001	3	31
SCLC	NCF2 →	+1.867	+0.176	<.001	<.001	3	31
LAML	SIGLEC9 →	+1.658	+0.136	<.001	<.001	3	31
LAML	LILRB2 →	+1.895	+0.131	<.001	<.001	3	31
SCLC	MYO1F →	+1.499	+0.184	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098883 vs C1QA — BLCA

Explore this scatter interactively →