Synapse pruning

Across TCGA patient cohorts, RNA activity of the Synapse pruning pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, ADGRE2, and MEFV, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse pruning activity versus BCL2A1 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BCL2A1 →	+1.315	+0.197	<.001	<.001	3	9
OV	ADGRE2 →	+0.544	+0.147	.001	.002	3	9
UCEC	MEFV →	+0.738	+0.202	<.001	<.001	3	8
PDAC	CSF3R →	+0.888	+0.172	<.001	<.001	3	8
COAD	ITGAX →	+1.059	+0.169	<.001	.001	3	8
OV	FCGR2A →	+1.221	+0.227	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098883 vs BCL2A1 — OV

Explore this scatter interactively →