Neurotransmitter receptor transport to plasma membrane

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor transport to plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRIP1_S847, SIPA1, and SLC1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor transport to plasma membrane activity versus GRIP1_S847 in GBM (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRIP1_S847 →	+0.957	+0.086	<.001	<.001	3	6
BRCA	SIPA1 →	-0.147	-0.033	<.001	.001	3	5
BRCA	SLC1A1 →	+1.092	+0.062	<.001	<.001	3	5
BRCA	ADGRE5 →	-0.369	-0.038	<.001	<.001	3	5
BRCA	ALDH1L2 →	-0.431	-0.039	.007	.008	3	5
CCRCC	ZEB2 →	-0.181	-0.059	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098877 vs GRIP1_S847 — GBM

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