Neurotransmitter receptor transport to plasma membrane

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor transport to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8orf33, ATP6V1H, and POLB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor transport to plasma membrane activity versus C8orf33 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C8orf33 →	+0.550	+0.580	.001	.004	3	5
CCRCC	ATP6V1H →	+0.366	+0.953	.002	<.001	3	4
LSCC	POLB →	+0.466	+0.624	.008	.001	3	4
BRCA	ARHGAP39 →	+0.628	+0.603	.004	.002	3	3
BRCA	LRRC14 →	+0.563	+0.749	.001	<.001	3	3
BRCA	SHARPIN →	+0.604	+0.666	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098877 vs C8orf33 — BRCA

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