Neurotransmitter receptor transport to plasma membrane

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor transport to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2BP1, HMGA1, and TRMT10B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF2BP1 grouped by Neurotransmitter receptor transport to plasma membrane-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IRF2BP1 →	-0.863	-1.187	<.001	.003	3	5
LIVER	HMGA1 →	+0.981	+1.375	.002	<.001	2	5
LUNG_SCLC	TRMT10B →	-1.010	-1.209	.004	.007	2	5
OVARY	KDM8 →	-0.456	-1.362	.006	<.001	3	4
STOMACH	KMT2B →	-1.028	-0.354	.001	<.001	3	4
OVARY	PLA2G6 →	-0.726	-1.069	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF2BP1 by Neurotransmitter receptor transport to plasma membrane activity — LUNG_SCLC

Explore this box plot interactively →